中文关键词：DNA甲基化，基因沉默，siRNA
英文摘要：
The most familiar action of mode performed by RNA regulation is the posttra criptional gene silencing in the cytoplasm. The discovery of siRNA-directed DNA methylation in nucleus has proved that siRNA can induce tra criptional gene silencing by siRNA-guided genome modificatio . DNA methylation was once predicted to be an epigenetic mechanism of tumor biogenesis. It is well known that the a ormal inhibition of tumor-su re or genes is a ociated with DNA de novo methylation in the gene promoter region. Potential molecular mechanisms of tumour-su re or gene silencing was analized, the principle of siRNA-directed tra criptional su re ion was explored, and the po ible relatio hip between them was clarified. The detailed study on the relatio hip between DNA methylation and RNA interference will be beneficial to better understand tumor biology and epigenetics, and also provide new therapeutic strategies for the prevention and treatment of cancer.
英文关键词：DNA methylation, gene silencing, siRNA
全文见附件1
http://www.biotech.org.cn/news/news/file/20060208095032.pdf
来源：中国生物技术信息网