4.5 抗CD33单克隆抗体在APL的临床应用 非结合人原化抗CD33单抗（HUM195）首先应用在ATRA治疗APL，CR后检测PML/RARα，MRNA阴性，经2～3个疗程后80%的APL患者PML/RARα转阴。
2002年美国首先应用CMA-676（GO）治疗复发的老年APL患者12例，一个疗程后获得了8例CR的好成绩，继而FDA批准GO 应用于复发的老年APL的一线治疗。[16]
参考文献：
[1] 孙 燕.肿瘤的综合治疗[M].见孙燕主编.中国临床肿瘤学教育专辑.中国医药科技出版社,2003,207. 2000.
[2] 2002年全国小儿血液病学术会议论文文汇编. 中华医学会. 2002.9.
[3] I-BFM-SG protocol and committee Progre report,P10,BFM-Austria•Germany• witzeri•and, ALL-BFM Pilot and ALL-BFM 2000[J].Preliminary report,2003.
[4] Naito K, Takeshita A, Matsui H, et al. Multidrug resistance (MDR)-related protein 1 (MRP1) and lung resistance protein (LRP) are not the main drug resistance mechanisms of gemtuzumab ozogamicin (CMA- 676) in AML[J].Hematol J ,2003,3:1048.
[5] Matsui H, Takeshita A, Naito K, et al. Reduced effect of gemtuzumab ozogamicin (CMA-676) on Pglycoprotein and•or CD34 positive leukemia cells and its restoration by multidrug resistance modifiers[J].Leukemia, 2002,16:813-819.
[6] Kantarjian H, Sawyers C, Hochhaus A, et al.Hematologic and cytogenetic re o es to imatinib mesylate in chronic myelogenous leukemia[J]. N Engl J Med ,2002,346:645-652.
[7] IBMTR ABMTR Summary slides 2003,Volume 10 l ue 1 Novemeber 2003.
[8] Hoover RR, Mahon FX,Melo JV,et al.Overcoming STI571 resistance with the farnesyl tra ferase inhibitor SCH66336[J].Blood, 2002,100:1068-1071.
[9] Guglielmi C, Arcese W, Dazzi F, et al. Donor lymphocyte infusion for rela ed chronic myelogenous leukemia: prognostic relevance of the initial cell dose[J].Blood, 2002,100:397-405.
[10] 10. Ma J, Liu JW, Chen LY, et al. Clinical o ervatio on arsenic trioxide (As2O3)and all-tra retinoic acid (ATRA)in the treatment of acute promyelocytic leukemia(APL) [J].Blood,1998,92(su l 1):483a.
[11] 马 军. 三氧化二砷治疗难治性APL[M].见:孙燕主编.中国临床肿瘤学教育专辑.中国医药科技出版社,2000.203-207.
[12] Wang ZY, Chen Z. Differentiation and apoptosis induction therapy in acute promyelocytic leukemia [J] . Lancet Oncol, 2000,1:101-106.
[13] Wzhang, ZY. Treatment of Acute Leukemia by Inducing Differentiation and Apoptosis[J].Blood,2003:1-4.
[14] 黄世林,郭爱霞,向 阳,等.复方青黛片治疗APL的临床研究[J].中华血液学杂志,1995,16:26.
[15] Lu DP, Qiu JY, Jiang B, et al. Tetra-arsenic tera-sulfide for the treatment of acute promyelocytic leukemia: a pilot study[J].Blood,2002,99:3136-3143.
[16] 高久史磨. 血液.2003年日本中外医学社,2003.86-95.
[17] HEMATOLOGY. 2003 American Society of Hematology Education Program Book.
来源：ＣＳＣＯ论坛