肝癌  胃癌  膀胱癌  食管癌  皮肤癌  纤维肉瘤  睾丸肿瘤  子宫颈癌  子宫内膜癌  脑垂体腺瘤
肾癌  喉癌  尿道癌  乳腺癌  淋巴瘤  甲状腺癌  绒毛膜癌  颞叶肿瘤  支气管腺瘤  神经胶质瘤
肺癌  脑瘤  白血病  外阴癌  结肠癌  黑色素瘤  前列腺癌  输卵管癌  尤文氏肉瘤  鳞状细胞癌
鼻咽癌  胰腺癌  大肠癌  直肠癌  卵巢癌  胆囊癌  艾滋病  软骨瘤  阴茎癌  血瘤  贲门癌  骨肉瘤

ATO-淋巴瘤集锦

e activated T cells a ociated with a poor prognosis. The combination of the antiviral agents, zidovudine (AZT) and interferon (IFN), is a potent treatment of ATL. Recently, arsenic trioxide (As) was shown to be an effective treatment of acute promyelocytic leukemia (APL). We have tested the effects of the combination of As and IFN on cell proliferation, cell cycle phases distribution, and apoptosis in ATL-derived or control T-cell lines. A high synergistic effect between IFN and As was o erved in ATL-derived cell lines in comparison to the control cell lines, with a dramatic inhibition of cell proliferation, G1 arrest, and induction of apoptosis. Similar results were obtained with fresh leukemia cells derived from an ATL patient. Although the mechanisms involved are unclear, these results could provide a rational basis for combined As and IFN treatments in ATL.

Leukemia 1998 Se 12(9):1383-91

The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.

Zhang W, Ohnishi K, Shigeno K, Fujisawa S, Naito K, Nakamura S, Takeshita K, Takeshita A, Ohno R.

Department of Medicine III, Hamamatsu University School of Medicine, Japan.

Arsenic trioxide (As2O3) has recently been shown to induce complete remi ion in acute promyelocytic leukemia (APL). As2O3 reportedly has dose-dependent dual effects on APL cells, triggering apoptosis at relatively high concentratio and inducing differentiation at lower concentratio . However, its effect is still controversial for other AML cells and hematological neoplasms. We studied the in vitro effect of As2O3 on lymphoid lineage cells: lymphoma cell lines, NOL-3, Raji and Daudi, a myeloma cell line, NOP-1, normal peripheral blood lymphocytes ( L), non-Hodgkin\'s lymphoma (NHL) cells and chronic lymphocytic leukemia (CLL) cells, and compared it with the effect on APL cell line, 4, as well as other myeloid cell lines, HL-60 and NKM-1. As2O3 at a concentration of 1 micromol/l markedly inhibited both proliferation and viability of 4, NOP-1, NOL-3 and NKM-1 cells, but it reduced only viability in normal L, CLL cells and NHL cells. As2O3 induced apoptosis and down-regulated bcl-2 expre ion in 4, NOP-1 and NKM-1 cells. On the other hand, in HL-60, Raji and Daudi cells, 1 micromol/l As2O3 inhibited only the proliferation weakly, and neither induced apoptosis nor down-regulated bcl-2 expre ion, but arrested only cell cycle at G1 phase. As2O3 at a low concentration of 0.1 micromol/l had no effect on proliferation and viability of these cells except for 4. These results showed that As2O3 exerted variable and definite effects on lymphoid cells and indicated that As2O3 might be clinically useful in lymphoid neoplasms such as malignant lymphoma and CLL.

Br J Haematol 1998 Se 102(4):1055-60

Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of ca ases and down-regulation of Bcl-2 protein.

Akao Y, Mizoguchi H, Kojima S, Naoe T, O

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